Pancytopenia and scleroderma.

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چکیده

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Posttransplantation and pancytopenia.

A 33-year-old female with a history of a live related renal transplant on azathioprine and prednisolone and tacrolimus was asymptomatic until 3 years later when she developed low-grade fever, epigastric discomfort, and headache. She had hepatosplenomegaly but no lymphadenopathy. Complete blood counts revealed pancytopenia with hemoglobin 79g/L, leukocyte count 2.6 109/L, platelet count 38 109/L...

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Scleroderma with Nodular Scleroderma

BACKGROUND Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type. Treatment is challenging, and several treatments modalities have been reported with unsatisfactory results. MAIN OBSERVATIONS We present a case of systemic scleros...

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The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become proble...

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ژورنال

عنوان ژورنال: BMJ

سال: 1976

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.6023.1446